What is a Biotech Cleanroom?

scientist working in biotech cleanroom

Biotech cleanrooms are used in various industries, such as medical and agricultural  to meet the specific needs and requirements of the projects. They can be used in different ways, but they always must meet strict environmental control standards. To understand the complexity of biotech cleanrooms, we should talk about biotechnology and its applications.

biotechnology at work

Types of Biotechnology

Biotechnology is a branch of technology based on biology used to study and improve life by using plants, animals, and nature to enhance different areas of human life. Biotech cleanrooms make this study possible by creating and maintaining an extremely controlled environment so nothing could contaminate the experiments. There are three main biotechnology applications.

  • Medical Biotechnology. Certain medical cleanrooms could also be considered biotech cleanrooms as two fields do similar studies. Diagnostics, forensics, vaccinations, and medicinal therapy productions are just a few biotechnology applications. A variety of significant health care research, such as cancer, gene therapy, and stem cell research, is conducted in biotech cleanrooms as they require the highest level of contamination prevention for the safety of staff and patients. 
  • Agricultural Biotechnology. Another primary application of biotechnology is the study of biology related to crops and food products. Agritech uses modification techniques to improve the nutritional content and flavor of food. However, other applications include developing non-food products, biodegradable materials, vegetable oils, biofuel, etc. 
  • Environmental Biotechnology. This biotech application studies our environment and how human actions affect it. For this application, biotech cleanrooms are designated to research and test biological samples, determine if products are safe for the environment, and conduct environmental cleaning and monitoring. 
scientists having a discussion in biotech cleanroom

Biotech Cleanroom Classifications

These applications are very precise and require stringent cleanliness standards to develop and test new treatments and compounds. Almost all biotech cleanrooms must comply with ISO 14644-1 Class 5 or stricter cleanroom classifications. ISO Class 1-5 are considered to have extremely strict standards. Even though the biotech cleanrooms follow the ISO classification guidelines, they must also be outfitted appropriately for the chosen processes to operate effectively and efficiently. The air purity is of great concern, and the constant air velocity should be 40-80 feet per minute. Environmental control and air purity should be up to standards to ensure products and processes are not affected by contamination. 

biotech cleanroom worker

Biotech Cleanroom Type

The design of the biotech cleanroom is fundamental. To operate safely and efficiently, the cleanroom should be flawlessly designed to avoid interruptions and the risk of contamination. It should incorporate unique features to a given application, such as air filtration, HVAC, individual processing systems, and more. 

In order to achieve stringent standards of ISO Class1-5 classification, most biotech applications require HardWall type cleanrooms. HardWall cleanrooms consist of seamless wall panels, flooring, and ceiling grid, preventing dust or dirt particles from settling. The panels and other surfaces are made of non-corrosive and non-shedding materials, which could sustain harsh cleaning procedures. 

Biotech Cleanroom Systems

There are many systems within a biotech cleanroom that support its everyday functions. These systems are responsible for maintaining the environment controlled, clean, and consistent so that the stringent classifications are reached at all times. Some of the systems include HVAC, filtration, and pressurization. 

  • Cleanroom filtration: Air filtration is required in biotech cleanrooms to maintain a high level of air quality using a laminar airflow pattern and HEPA filtration. 
  • Cleanroom HVAC: In biotech cleanrooms, robust HVAC systems supply the cleanroom with temperature and humidity-controlled air. 
  • Cleanroom pressurization: Depending on the applications, some biotech cleanrooms require pressurization so that dangerous fumes or substances can be isolated to protect sensitive processes. Positive and negative pressure cleanrooms have a wide range of uses as biotech cleanrooms in many industries, from medical development and research to manufacturing food products and devices. 

A biotech cleanroom is a significant part of many industries and applications. A top-of-the-line cleanroom design is required to be successful and to have an uninterrupted workflow that meets all the classification requirements. 

If you think biotech cleanroom is right for your application, get in touch with our team of experts. We can provide biotech cleanroom design, build, and installation tailored to your industry’s unique needs.